Synbiotic 365 is a probiotic supplement from United Naturals – a digestive health company. From the official website and elsewhere, you will find some very positive reviews for the product. It can help with digestive issues, promote digestive health, and can replenish the gut flora. However, there may be too much going on with this product. It is a possibility that Synbiotic 365 has gone slightly overboard with its components. Before we look at this United Naturals product closer, you must understand how the gut works and how the gut can get hurt.
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If you are not aware of gut bacteria, you wouldn’t be alone. In your intestine, an entire bio-network of microbes thrives, the health of this bio-network determines the health of the body. The automatic reaction to microbes is to get them out of your system but if you were to remove the microbes from your gut, you would have to kiss your immune system, skin health, hormone balance, healthy digestion and bowel movements, heart health, cognition, mood, and brain health goodbye. The ecosystem in the gut is called the gut microbiome. Of all the little guests, it is the bacteria that help us the most, at least the good bacteria do. In every gut, you will find good and bad bacteria constantly trying to outdo the other. As long as the good ones are winning, the gut is fine. When the bad ones get a one-up, the result is havoc. In mild cases of gut imbalance- dysbiosis, the digestive system can correct it without any external help. When the gut is suffering, you will have some tell-tale signs like:
- Bad breath
- Upset stomach – gas, bloating, diarrhea, or constipation
- Nausea
- Vaginal or rectal infections
- Food cravings especially for sugar
- Chest pain
- Fatigue
- Brain fog or trouble concentrating
- Anxiety
- Depression
Dysbiosis has been shown to be closely linked to certain diseases or medical conditions like celiac disease, candida, obesity, IBS, colitis, PCOS – polycystic ovary syndrome, food allergies, and leaky gut syndrome. All these conditions are bad but the leaky gut syndrome can be the root of yet more medical problems. You see, intestines are built in such a way that there are spaces that allow water and nutrients to move from within the intestine to the bloodstream. When you have leaky gut syndrome, the spaces in the intestines widen, allowing toxins, bacteria, and undigested food to enter the bloodstream. This leads to inflammation and hurts almost every other system in the body.

Natural Fixes for the Gut
There are some natural ways that you can avoid this fate but it would involve some lifestyle changes.
- Diet: It has been proven through clinical research that the more varied your diet, the more diversity in the gut flora. This is a good thing as the more strain of bacteria you have, the more benefits you reap. Switch to plant foods if you can as the fiber content feeds the good bacteria and keeps them healthy. Avoid junk and processed foods. Add fermented foods to your diet as they naturally replenish the good bacteria in the gut.
- Stress: Try to get your stress levels under control. There is plenty of scientific evidence that states that stress can adversely affect the gut microbiome. Stress also affects sleep cycles, quality of sleep, eating habits, and mental acuity. These further deteriorate gut integrity. Exercise, meditation, nature walks, and yoga are all good ways of combating stress and keeping it from hurting your body.
- Substance Abuse: Too much alcohol or tobacco intake can hurt the gut flora. Gut health is adversely affected, especially in the case of alcohol, so avoid it when you can.
- Antibiotics: These medications are designed to kill off disease-causing bacteria. However, it can also harm the good bacteria in the gut which leads to dysbiosis. Keep antibiotics to a minimum and take them only if absolutely needed.
- Dietary Supplements: Introducing prebiotic and probiotic supplements are also crucial to maintaining a healthy digestive system. They give you the right components in the right quantities to ensure that your gut is happy.
This is where United Naturals Synbiotic 365 comes in. A dietary supplement that includes carefully researched probiotic blends to warrant peace in your digestive tract.
- Probiotic supplements are those that replenish the numbers of good bacteria in the gut by introducing new and diverse beneficial strains into your system.
- Prebiotic ones are those that are food for the probiotic bacteria to keep them nourished and ready for action.
One such probiotic gut supplement we are going to review today, and find out if it is worth the investment made.
United Naturals Synbiotic 365 Review

A probiotic supplement is only as good as its ingredients. Since the boom in the gut health industry, a lot of dietary supplements have made their way to the market containing a blind combination of bacterial strains and a smattering of herbs to make the supplement appear natural and organic. That doesn’t quite make the cut. For a probiotic supplement to work, the bacteria strains that are introduced into the system must
- be of some benefit to the host,
- work in harmony with the host’s digestive system, and
- work in harmony with the bacteria strains already present in the gut.
Synbiotic 365 does seem to do a decent job of checking all the boxes. Additionally, it also contributes to your B vitamins intake for the day. And it is in capsule form.
The company recommends that you start one capsule a day with water. If you want you can take two pills a day but that means that a pack would last you only 15 days. The cost is a little steep as it is, and taking two pills a day would up the expense to an average of $90 a month, should you choose to buy just the monthly supply. There are discounts available on the official United Naturals website, if you opt to buy multipacks.
Let’s take a closer look at the Synbiotic 365 ingredients. The supplement uses two genera of bacteria that, through medical research, have been found to be the most beneficial to the human gut – Lactobacillus, and Bifidobacterium strains.

- Lactobacillus Grasseri: This strain of bacteria helps to maintain healthy vaginal flora and can also aid in weight loss. It was found that Grasseri was able to reduce inflammation in the colon which can directly reduce the occurrence and severity of IBS and ulcerative colitis symptoms.
- Lactobacillus Plantarum: Already used in treatment for various chronic and cardiovascular conditions, Plantarum has been found beneficial for diabetes, obesity, cancer, hypertension, liver disorders, and urinogenital distress. It can be easily acquired from fermented foods such as brined olives, cheeses, and stock fish.
- Lactobacillus Casei: Casei has been historically used to treat digestive issues and travelers’ diarrhea. Sometimes it is used to treat colic in infants. Effective with the symptoms of IBS, IBD, Crohn’s disease, and constipation, Casei can also decrease the severity of allergies, urinary infections, oral health problems, and respiratory infections.
- Lactobacillus Paracasei: In addition to digestive health benefits, Paracasei helps to improve the immune system, and reduce oxidative stress – by helping the removal of free radicals, and weight control. It can also help improve the CFUs (colony forming unit) of beneficial bacteria in the body and reduce the number of bad bacteria.
- Lactobacillus Rhamnosus: One of the most widely used bacteria strains in dietary supplements, Rhamnosus, helps with the prevention and treatment of gastrointestinal infections, and diarrhea, prevents allergies and promotes immune responses.
- Lactobacillus Reuteri: This bacterial strain is found in several body sites like the gut, skin, breast milk, and urinary tract and is cited as the microbe to best treat yeast infections. Gut flora can also be improved and digestive issues are taken care of once this strain is introduced into the system.
- Lactobacillus Salivarius: Already a resident of almost every gastrointestinal gut. Salivarius can help improve the beneficial bacteria population in the mouth, reducing the chances of gum plaque. It is also known to safeguard dental hygiene. It also produces hydrogen peroxide and other compounds and can grow and multiply very quickly – it helps to crowd out pathogens.
- Lactobacillus Fermentum: As the name suggests, it is commonly found in fermenting plant and animal matter. Fermentum has quite a few potential benefits like cholesterol control and boosting immunity function. It can particularly help with issues that plague women like yeast infections and UTIs.
- Bifidobacterium Bifidum: This strain of bacteria can contain and treat the symptoms of IBS and has the strongest influence on immunity. It recruits white blood cells to fight off infection. It helps with eczema in infants as well.
- Bifidobacterium Lactis: Lactis is a multi-talented probiotic bacterium that lives in the gut. It can fight tumor growth, enhance immunity, improve digestive health, and effectively treat IBS symptoms. It can, in not-so-severe cases, single-handedly correct leaky gut by lowering the permeability of the intestinal wall.
- Bifidobacterium Longum: Effective in eliminating gastrointestinal distress and immunological disease, Longum is attributed to maintaining the intestinal environment to promote healthy gut flora. Longum increases the skin’s resistance to temperature and product-related irritation.
- Bacillus subtilis: Also known as hay bacillus, this bacterium is a multifunctional probiotic that can improve nutrient absorption and can also curb the growth of pathogens in the gut. It can boost immune responses, and the healthy metabolism of lipids and have several other health benefits.
- Streptococcus thermophilus: Usually used as a fermenting agent, you can find this bacterium in everyday yogurt and cheese. Traditionally Thermophilus is used to treat diarrhea, constipation, and colic in children, and is used in dietary supplements for the gut. It also boosts the body’s fermenting process in the small intestine.
- Saccharomyces boulardii: This is a tropical yeast harvested from mangosteen and lychee fruit peels. Essentially used for treating diarrhea, especially in children, it is used for skin irritations, digestive tract infections, and ulcers and maintains overall gut health. It is a useful and sometimes necessary replacement for antibiotics in case of diarrhea.
United Naturals Synbiotic 365 gives you an impressive dose of probiotic strains daily and it helps you supplement vitamin B as well. By including the ever-important B complex vitamins, Synbiotic 365 ensures that your body doesn’t suffer from Vitamin B deficiencies and can also help with cravings.
- Vitamin B complex:
- B1 – Thiamine: B1 enables your body to use carbohydrates as energy and glucose metabolism would not be possible without it. B1 supports nerve muscle integrity and heart health. A deficiency would be characterized by nerve damage, blurry vision, fatigue, nausea, or delirium.
- B2 – Riboflavin: B2 is crucial to the breaking down of fats, proteins, and carbohydrates and ensures that your body has a constant steady supply of energy. B2 helps to convert carbohydrates into ATP – a source of energy for use and storage at a cellular level. Deficiency of B2 would result in vision loss, swollen throat, fatigue, and depression.
- B3 – Niacin: This B vitamin can help lower cholesterol, ease arthritis and boost brain function. B3 can boost blood fat levels, regulates blood pressure, and improve skin health. Skin rashes or discoloration, vomiting, fatigue, headaches, and memory loss are all signs of a deficiency. A large dose of B3 can have serious side effects.
- B5 – Pantothenic Acid: Similar to B2, B5 enables the breakdown of food into usable compounds. More importantly, B5 is vital to the manufacture of red blood cells and helps with the production of sex and stress hormones by boosting the adrenal glands. A deficiency is marked by headaches, restlessness, disturbed sleep, and muscle cramps.
- B6 – Pyridoxine: Often used to supplement antidepressant medication, B6 is also used to promote brain health, prevent anemia, treat PMS, and boost enzyme reaction and treat morning sickness. It also boosts the immune and nervous systems and ensures normal brain development during pregnancies. Numb hands and feet, sore and cracked tongue and brain fog or confusion may be signs that you are running low on B6.
- B7 – Biotin: This B vitamin promotes nervous system function and metabolism of the liver as well. It is almost always found in supplements for hair, skin, and nails. Biotin is known for aiding cell growth and the maintenance of mucous membranes in the body like the one that protects the gut wall. Low levels of B7 result in deteriorating health of hair and nails and red rashes all over the body.
- B9 – Folate: Central to the production of DNA and RNA, B9 is needed when cells and tissues are growing rapidly, like with adolescents and infants. Folate works with B12 to help with the absorption of iron and the creation of red blood cells.
- B12 – Methylcobalamin: B12 keeps your body’s blood and nerve cells healthy and helps with the making of the body’s genetic material. It is also used to prevent and treat a blood condition called megaloblastic anemia. A B12 deficiency results in a reduction of healthy blood cells and the nervous system can also be affected.
- B1 – Thiamine: B1 enables your body to use carbohydrates as energy and glucose metabolism would not be possible without it. B1 supports nerve muscle integrity and heart health. A deficiency would be characterized by nerve damage, blurry vision, fatigue, nausea, or delirium.
- Chicory Root Inulin: Fresh chicory root is almost 68% inulin – a fiber known as fructan that the body cannot digest. The fiber is prebiotic that feeds the bacteria in the gut as they can break the inulin down into usable compounds. Because of the inulin, the beneficial bacteria are kept healthy and nourished which benefits a healthy gut. Because of the fiber, inulin also adds bulk to the stool which results in constipation relief and soft stools. Chicory Root inulin takes time to move through the system, thereby making you feel fuller for longer. This aids weight loss. It also aids blood sugar levels, especially in diabetics.
Synbiotic 365 has used an advanced probiotic formula along with b vitamins and inulin. The recipe does seem impressive but does the supplement actually work to correct gut distress?
What does Synbiotic 365 have going for It?
On the whole, Synbiotic 365 doesn’t seem like too bad a supplement. There are definitely certain benefits to using it.
- Because of the probiotic blend used, it is possible for Synbiotic 365 to lower the pH of the colon and improve bowel regularity.
- Combining probiotics and essential vitamins seems like a good idea as gut disorders can sometimes cause nutritional deficiencies and Synbiotic 365 may be able to cover for the loss.
- Synbiotic 365 is GMO-free, gluten-free, dairy-free, soy-free, egg-free, and nut-free. The product is vegan friendly and the chances of allergic reactions are kept to a minimum.
- As a digestive health product, Synbiotic 365 does work due to the various probiotic strains used. The diversity of bacteria in the gut is a good thing.
- Vitamin B deficiencies are corrected.
- Many users have reported better sleep and improved energy levels after partaking in the product.
- Should you not be happy with the product there is a money-back guarantee.
If you only look at this much, Synbiotic 365 begins to look really good. However, there is always a flipside and Synbiotic 365 has one too.
Why Give Synbiotic 365 a Miss?
To be clear, Synbiotic is among the better supplements out there but there are a few drawbacks to using this United Naturals product.
- As a product that claims to resolve digestive issues, there have been quite a few reports of gas, bloating, and nausea after the use of this product.
- The use of b vitamins along with the probiotic blend can sometimes work against you. Thiamin and Niacin may cause sweating, itching, and nausea when taken in higher doses.
- The doses in Synbiotic 365 are slightly higher than the recommended daily dosage and there is a chance that it may adversely affect you.
- The doses in Synbiotic 365 are slightly higher than the recommended daily dosage and there is a chance that it may adversely affect you.
- The use of L.Grasseri in the blend makes taking Synbiotic 365 impossible for some. For those who are immunocompromised from chemotherapy, Grasseri can lead to heart health issues.
- The use of this product is not recommended for pregnant or breastfeeding women as there aren’t any peer-reviewed studies surrounding the effects this strain may have on mothers.
- The use of this product is not recommended for pregnant or breastfeeding women as there aren’t any peer-reviewed studies surrounding the effects this strain may have on mothers.
- As compared to other probiotic supplements, Synbiotic 365 is expensive. Other products give you similar results for much less.
- Vitamin b deficiencies aren’t all that common and losing weight will be a result that you will get when you have a healthy gut. Synbiotic 365 does nothing extra in the weight loss department.
Testimony
Audrey A. (USA)
I have been using Synbiotic 365 for a few weeks now and I have definitely noticed a difference in my digestion. I used to suffer from bloating and occasional stomach discomfort, but since taking this supplement, those symptoms have greatly improved. I also appreciate that it is a probiotic and helps to replenish the good bacteria in my gut. Overall, I think Synbiotic 365 is a good product for improving digestive health, but I would definitely recommend this product.
Kendell A. (UK)
I recently purchased Synbiotic 365 and I have mixed feelings about it. On one hand, it did help with my digestive issues and I did notice an improvement in my gut health. That being said, it did work for me and I would recommend it to others who are struggling with digestive problems.
Synbiotic 365 Review Summary
When you look at the claimed benefits you reap from Synbiotic 365, it doesn’t sound like a shoddy supplement at all. The components used in the product do have several positive results, not just for the gut but for overall health as well. Synbiotic 365 can potentially lower cholesterol, boost energy, cause weight loss, fix gut issues, and keep the gut healthy with one pill a day. However, you can’t disagree that gut disorders are caused by poor eating habits and lifestyle choices. A supplement cannot change that overnight. With Synbiotic 365, you would need to make some significant changes to your life to see any visible changes. Also, because of the use of specific components and the doses in which they are used, you may want to speak to a healthcare provider before you start the product.
There are some products out there that don’t have most of these side effects. Probiotics are beneficial to you but combining probiotics with potentially side-effect-driven components is not working for Synbiotic 365. Before you choose to buy this United Naturals product, do compare it to products like Gut+ or Biotics 8 or find out about the Top 10 Best Probiotic Supplements to get a better idea of what other supplements can do for you.